Accelerating Molecular Glue Discovery with CBM/PDL Platforms for Novel Target Engagement
- Leveraging a structurally distinct cereblon-binding module (CBM) library to recruit novel neosubstrates beyond traditional thalidomide analogues
- Deploying a proteomics-based degron library (PDL) to predict degron motifs and prioritize new molecular glue degrader (MGD) targets
- Highlighting case studies of MGD discovery and optimization to expand druggable target space