Ryan Potts

Ryan Potts

Company: Amgen

Job title: Executive Director & Head of Induced Proximity Platform


Targeting the Ubiquitin Pathway through Tissue-Specific Regulators 3:30 pm

Ubiquitin ligases can be redirected to target neosubstrates for ubiquitination by endogenous, tissue-specific protein regulators, akin to small molecule PROTACs MAGE proteins are testis-specific ubiquitin ligase regulators that are upregulated in cancer and reprogram ligases towards neosubstrates to drive tumorigenesis Discovery of small molecule regulators of MAGEs enable targeting the ubiquitin pathway specifically in cancerRead more

day: Day Two

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