Ray Deshaies

Ray Deshaies

Company: Amgen

Job title: Senior Vice President of Global Research


Structure and Dynamics of CRLomes: Implications for Targeted Protein Degradation 3:30 pm

• Some of the most commonly used ligands for assembling PROTACs work through cullin-RING ubiquitin ligases (CRLs) • Active CRLs are composed of a core catalytic unit (cullin+RING domain protein+adaptor protein) assembled with one member of a large family of different substrate receptors that in aggregate are present in excess over the core catalytic unit…Read more

day: Day Two

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