Leah Fung

Leah Fung

Company: BioTheryx

Job title: CSO Biology


Novel Small Molecule Bifunctional Degraders of SOS1 For Inhibition of Pan-KRAS Mutant Cancers 9:00 am

• Kirsten rat sarcoma (KRAS) is the most frequently mutated oncogene in human cancer. The guanine nucleotide exchange factor, son of sevenless homolog 1 (SOS1), exchanges GDP for GTP in KRAS, inducing activation of KRAS • Biotheryx’s PRODEGY platform has enabled the discovery of bifunctional molecules that demonstrate rapid, deep, proteasome-dependent degradation of SOS1 •…Read more

day: Day Two

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