New Approaches to Degradation – Beyond the Usual Suspects

Time: 9:30 am
day: Day Two


  • First public disclosure of the Amphista platform using a completely novel range of mechanisms to degrade a wide range of disease-relevant proteins
  • Mechanisms go beyond the usual E3 ligases utilized by most in the field and instead use other UPS proteins which offer new opportunities to expand the scope and utility of TPD strategies
  • We will discuss how novel mechanisms have the potential to overcome current limitations with TPD strategies