Pre-Conference Bootcamp Day

Tuesday, October 25

Want to understand the basic principles and familiarize yourself with key terms and technologies?

Look no further than the TPD 101 Bootcamp Day at the Targeted Protein Degradation Summit where you will learn the important foundations of the field preparing you and increasing your confidence in the discussions that lie in the deeper-dive days ahead!

8:00 am Registration & Coffee Morning

8:25 am Chair’s Opening Remarks

  • Nan Ji CEO, PAQ Therapeutics

8:30 am Diversity, Equality & Inclusion Panel Discussion

  • Jullian G. Jones CBO, Monte Rosa Therapeutics
  • Lingling Shen Associate Director - Data Science & Chemical Biology & Therapeutics Chemical Biology & Therapeutics, Novartis AG

Synopsis

For more information on this session, please download the full event guide.

9:15 am An Introduction to Targeted Protein Degradation

Synopsis

For more information on this session, please download the full event guide.

9:45 am High-Throughput Assay Technologies for Accelerating the Discovery & Enhancement of Targeted Protein Degradation Therapeutics

Synopsis

For more information on this session, please download the full event guide.

10:15 am Discovery of New Targeted Protein Degraders using DNA-Encoded Chemistry

Synopsis

  • Introduction to DNA-Encoded Chemical Library Technology (DEL)
  • Application of DEL to the discovery of new bispecific degraders
  • Case study showcasing the platform

10:35 am Degraders Versus Inhibitors: A Tale of Two Drug Discovery Modalities

  • Gisele Nishiguchi Principal - Lab Medicinal Chemistry , St. Jude Children's Research Hospital

Synopsis

For more information on this session, please download the full event guide.

11:05 am Morning Break & Refreshments

12:15 pm Cereblon Covalent Modulation through Rational Design of Histidine Targeting Chemical Probes

  • Justin Cruite Structural Biologist and Project Lead, Center for Protein Degradation, Dana-Farber Cancer Institute

Synopsis

For more information on this session, please download the full event guide.

12:45 pm Targeted Degradation as a Means to Address Resistance Common to Kinase Targeted Therapies

Synopsis

For more information on this session, please download the full event guide.

1:00 pm
Uncovering Mechanistic Insights for Degrader Discovery

1:15 pm Deep-Dive into the Mechanistic Understanding of Ubiquitination

Synopsis

For more information on this session, please download the full event guide.

1:45 pm Understanding the Ternary Complex Formation

Synopsis

For more information on this session, please download the full event guide.

2:15 pm Networking Lunch

3:15 pm Informatics Accelerated CRBN Glue Lead Discovery

  • Lingling Shen Associate Director - Data Science & Chemical Biology & Therapeutics Chemical Biology & Therapeutics, Novartis AG

Synopsis

For more information on this session, please download the full event guide.

3:45 pm Expression & Characterization of Novel Tissue Selective E3 Ligases

Synopsis

For more information on this session, please download the full event guide.

4:15 pm Round Table Discussions | Dissecting the Drug Development Pipeline

Discovery - Understanding early discovery considerations,
understanding terminology

Kevin Woller, Principal Research Scientist, Abbvie

 

Pre-Clinical - How to take your candidate
forward into animal studies and
understanding what species are best

Jacqueline Kinyamu-Akunda, Senior Scientific Director, Nonclinical Safety, Janssen R&D

Translation & Clinical - Understanding how to approach translational challenges to optimize clinical success

Chunhai Hao, Bicentennial Professor of Pathology & Laboratory Medicine, 
Indiana University

4:15 pm PK/PD Model-Informed Discovery of TPDs

Synopsis

  • Insights into PK/PD modelling approaches for TPDs
  • Understanding the unique PK/PD properties of degraders
  • Model-informed guidance of compound optimisation and study design
  • Translational approaches from in vitro to in vivo and from animal to human

5:00 pm End of Pre-Conference Bootcamp Day

WORKSHOP DAY
DAY ONE
DAY TWO