Post-Conference Focus Day
Friday, October 28
Next Generation Protein Degradation & Stabilization Strategies
PROTACs and molecular glues have put protein degradation as a therapeutic on the map for targeting difficult to drug targets, with promising early clinical results. Despite this, there are a plethora of new very exciting degradation approaches that are coming out of the woodwork. These next generation degraders have the potential to overcome challenges such as crossing the blood brain barrier, specificity, resistance and toxicity issues. With that comes a different set of specific challenges and exciting opportunities that could well go far beyond what existing degraders can achieve.
This dedicated focus day is your comprehensive deep-dive into emerging TACs for protein degradation, stabilization and modification.
8:55 am Chair’s Opening Remarks
Expanding the Horizon: Applying PROTACs in Farming & to Prokaryotes
9:00 am TPD: A New Modality in Agriculture
Synopsis
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9:30 am Bacterial PROTACs: Efficient Killing of M.Tuberculosis by Tag-Free Self-Degradation of an Essential Protein
Synopsis
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10:00 am Morning Break
Spotlighting Emerging Modalities Targeting Extracellular Proteins & Cell Therapy
11:00 am Extracellular Protein Targeted Degradation with Novel ATACs (ASGPR Targeting Chimeras)
Synopsis
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11:30 am Targeted Plasma Protein Degradation
Synopsis
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12:00 pm Targeted Protein Degradation for Cell Therapy
Synopsis
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12:30 pm Targeting Extracellular Proteins For Degradation Using Genetically Encoded Bi-Specifics
Synopsis
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1:00 pm Networking Lunch
Emerging DUB Platforms Taking Aim at Degradation & Stabilization
2:00 pm Ushering in the Novel Modality of Targeted Protein Stabilization (TPS)
Synopsis
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2:30 pm Proximity Control with PROTEINi Screening
Synopsis
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3:00 pm Reimagining Druggability using Chemoproteomic Platforms
Synopsis
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3:30 pm Afternoon Break
4:00 pm Phosphorylation-Inducing Chimeric Small Molecules
Synopsis
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Discovering the Potential of Biologic Degraders; Antibody neoDegrader Conjugates & bioPROTACs
4:30 pm Targeted2 Protein Degradation™ (TPD2): Dual Precision Degraders
Synopsis
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5:00 pm BioPROTAC: Next Generation Degraders Targeting the Most Undruggable Targets
Synopsis
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