Post-Conference Focus Day

Friday, October 28

Next Generation Protein Degradation & Stabilization Strategies

PROTACs and molecular glues have put protein degradation as a therapeutic on the map for targeting difficult to drug targets, with promising early clinical results. Despite this, there are a plethora of new very exciting degradation approaches that are coming out of the woodwork. These next generation degraders have the potential to overcome challenges such as crossing the blood brain barrier, specificity, resistance and toxicity issues. With that comes a different set of specific challenges and exciting opportunities that could well go far beyond what existing degraders can achieve.

This dedicated focus day is your comprehensive deep-dive into emerging TACs for protein degradation, stabilization and modification.

8:55 am Chair’s Opening Remarks

Expanding the Horizon: Applying PROTACs in Farming & to Prokaryotes

9:00 am TPD: A New Modality in Agriculture

Synopsis

For more information on this session, please download the full event guide.

9:30 am Bacterial PROTACs: Efficient Killing of M.Tuberculosis by Tag-Free Self-Degradation of an Essential Protein

Synopsis

For more information on this session, please download the full event guide.

10:00 am Morning Break

Spotlighting Emerging Modalities Targeting Extracellular Proteins & Cell Therapy

11:00 am Extracellular Protein Targeted Degradation with Novel ATACs (ASGPR Targeting Chimeras)

Synopsis

For more information on this session, please download the full event guide.

11:30 am Targeted Plasma Protein Degradation

  • Thomas M. Smith Associate Director, Novartis Institutes for Biomedical Research

Synopsis

For more information on this session, please download the full event guide.

12:00 pm Targeted Protein Degradation for Cell Therapy

  • Max Jan Assistant Professor, Massachusetts General Hospital

Synopsis

For more information on this session, please download the full event guide.

12:30 pm Targeting Extracellular Proteins For Degradation Using Genetically Encoded Bi-Specifics

Synopsis

For more information on this session, please download the full event guide.

1:00 pm Networking Lunch

Emerging DUB Platforms Taking Aim at Degradation & Stabilization

2:00 pm Ushering in the Novel Modality of Targeted Protein Stabilization (TPS)

Synopsis

For more information on this session, please download the full event guide.

2:30 pm Proximity Control with PROTEINi Screening

Synopsis

For more information on this session, please download the full event guide.

3:00 pm Reimagining Druggability using Chemoproteomic Platforms

Synopsis

For more information on this session, please download the full event guide.

3:30 pm Afternoon Break

4:00 pm Phosphorylation-Inducing Chimeric Small Molecules

  • Amit Choudhary Assistant Professor of Medicine, Harvard Medical School

Synopsis

For more information on this session, please download the full event guide.

Discovering the Potential of Biologic Degraders; Antibody neoDegrader Conjugates & bioPROTACs

4:30 pm Targeted2 Protein Degradation™ (TPD2): Dual Precision Degraders

Synopsis

For more information on this session, please download the full event guide.

5:00 pm BioPROTAC: Next Generation Degraders Targeting the Most Undruggable Targets

Synopsis

For more information on this session, please download the full event guide.

5:30 pm Chair’s Closing Remarks & End of 5th Annual Targeted Protein Degradation Summit