Targeting Mutant KRAS Oncoproteins with Molecular Glues: A TUBE-Based Screen Identifies a Novel Degradation Pathway
- Tandem Ubiquitin Binding Entity (TUBE) platform to discover novel molecular glues targeting mutant KRAS
- KRAS Mol Glue, coopting a novel E3 ligase to ubiquitinate and degrade mutant KRAS
- Pan KRAS degrader downregulates MAPK signaling
- Chain selective poly-ubiquitin TUBEs, K48 or K63, elucidate MOA of the compounds