• A tool compound (DT-061) selectively stabilizes B56α-containing PP2A heterotrimers, enhancing their pro-apoptotic functions and driving dephosphorylation of its oncogenic substrate, c-Myc
• Cryo-EM structure of DT-061 bound to its binding pocket identifies a trimeric interface of PP2A subunits, defining the molecular basis for its selective stabilization and therapeutic potential
• Structure-based drug design was used to develop new chemical compounds that also behave like molecular glues, but with improved pharmacokinetic properties

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